Clinical trial · Observational

A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome

In Modern Era, Recurrent Desmoids Determine Outcome in Patients With Gardner Syndrome: A Cohort Study of Three Generations of an Adenomatous Polyposis Coli (APC-) Mutation-Positive Family Across 30 Years

NCT01286662CI-TRIAL-00004376completedClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

The purpose of this study is to assess the long-term outcome in a cohort of Gardner-Syndrome patients receiving prophylaxis and treatment for intestinal and non-intestinal tumors.

Conditions

Conditions (3)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Colorectal Carcinoma	Colorectal Carcinoma	ONTOLOGY_EXACT	0.98
Desmoid Tumor	Desmoid Fibromatosis	ALIAS	0.90
Gardner Syndrome	—	UNRESOLVED	—

Interventions

Interventions (0)

Data not yet available

No intervention recorded.

Design

Arms and outcomes

Arms (0)

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Primary outcomes (1)

measure
mortality
timeFrame
1978-2010 (as long as patients live)

Secondary outcomes (2)

measure
incidence of colorectal carcinoma
timeFrame
1978-2010 (entire patient life)
measure
Incidence of desmoid tumors
timeFrame
1978-2010 (entire patient life)

Eligibility

Eligibility (as posted)

Sex: All

Show eligibility criteria text

Inclusion Criteria:

* family with an identical adenomatous polyposis coli (APC-) germ line mutation

Exclusion Criteria:

* negative testing for adenomatous polyposis coli (APC-) germ line mutation

References

Publications (1)

DERIVEDTurina M, Pavlik CM, Heinimann K, Behrensmeier F, Simmen HP. Recurrent desmoids determine outcome in patients with Gardner syndrome: a cohort study of three generations of an APC mutation-positive family across 30 years. Int J Colorectal Dis. 2013 Jun;28(6):865-72. doi: 10.1007/s00384-012-1600-x. Epub 2012 Nov 1. PMID 23114473