Study With Rituximab, Cyclophosphamide, Doxorubicin Liposomal (Myocet®), Vincristine, Prednisone, (R-COMP) to Treat Non-Hodgkin's Lymphoma

Inclusion Criteria:

* NHL histological diagnosis of diffuse large B cell CD20 + (de novo or shift from low-grade NHL if not pretreated), grade IIIb follicular NHL;
* Age \>= 18 years;
* Presence of at least 1 factor that defines the cardiopathy;
* Life expectancy \> 3 months;
* In the case of women of childbearing age absence of pregnancy at the beginning of the chemotherapy;
* Written informed consent.

Exclusion Criteria:

* Histology different from NHL diffuse large cell CD20 + or follicular IIIb
* Age \< 18 years
* Inability to sign informed consent;
* HIV positivity;
* Patients HBsAg positive;
* AST/ALT \> 2 times the standard;
* Bilirubin \> 2 times the standard;
* Creatinine \> 2.5 mg / dl;
* Location of CNS disease;
* Pregnancy ongoing;
* Damage to that organ or medical problems that could interfere with the therapy;
* Current uncontrolled infection;
* Senile dementia