Assessment of the Efficacy of the Neoadjuvant Combination: "Chemotherapy-Targeted Therapy" in Breast Cancer.

Inclusion Criteria:

* Age ³ 18.- Performance status £ 2 (according to WHO criteria).
* Patient has histologically confirmed, non-metastatic breast cancer, with a clinical tumour diameter of ³ 2 cm
* HR negative and Her-2 negative.
* Clinical stage II and IIIa.
* Patients not previously treated by surgery, radiotherapy, hormone therapy or chemotherapy.· Haematology: o Neutrophil count ≥1.5x109/Lo Platelet count ≥100x109/Lo Leucocyte count \> 3,000/mmo Hb\> 9g/dl· Hepatic Function:o Total bilirubin ≤ 1.5 time the upper normal limit (UNL)o ASAT ≤ 2.5xUNL in absence of liver metastases, or ≤5xUNL in presence of liver metastases ALAT ≤ 2.5xUNL in absence of liver metastases, or ≤5xUNL in presence of liver metastases Alkaline phosphatase ≤ 2.5 time the upper normal limit (UNL)· Renal Function· Creatinine clearance ≥50 mL/min and serum creatinine ≤1.5xUNL· Metabolic Function o Magnesium ≥ lower limit of normal. o Calcium ≥ lower limit of normal.
* Patient with no progressive heart disease, and for whom anthracyclines are not contraindicated (normal FEV).
* Patient has signed the consent forms for participation before inclusion in the trial.
* Member of a Social Security scheme (or a beneficiary of such a scheme) according to the provisions of the law of 9 August 2004.

Exclusion Criteria:

* Male patients.
* Her-2 positive patients
* Subject pregnant or breast feeding, or planning to become pregnant within 6 months after the end of treatment.
* Subject (male or female) is not willing to use highly effective methods of contraception (per institutional standard) during treatment and for 6 months (male or female) after the end of treatment.
* Any form of breast cancer other than those described in the inclusion criteria, particularly inflammatory and/or overlooked forms (T4b or T4d).
* Non-measurable tumour.
* Patients have already undergone surgery for their disease or have had primary axillary dissection.
* Patient has already been treated for new breast cancer.
* Patient is a ward.
* Patient has a history of second cancer, with exception of in situ cervical cancer or basocellular skin cancer which is regarded as cured.
* Patient has another disease which is deemed incompatible with the patient being included in the protocol.
* Heart or kidney failure, medullary, respiratory or liver failure.
* Clinically significant cardiovascular disease (including myocardial infarction, unstable angina, symptomatic congestive heart failure, serious uncontrolled cardiac arrhythmia) £ 1 year before enrollment/randomization
* History of interstitial lung disease e.g. pneumonitis or pulmonary fibrosis or evidence of interstitial lung disease on baseline chest CT scan
* Significant neurological or psychiatric abnormalities.
* Symptomatic or progressive disorder of the central nervous system (CNS) or metastasis at the initial check-up.
* Peripheral neuropathy \> grade 2 (NCI-CTCAE criteria, Version 3.0).
* History of allergy to polysorbate 80.
* Concomitant treatment with a trial drug, participation in another clinical trial within \< 30 days or previous chemotherapy.
* Patient with no fixed address in the next 6 months or living at a distance from the treatment centre so it is difficult to check her progress.
* Prior anti-EGFr antibody therapy (e.g.:cetuximab) or treatment with small molecule EGFr tyrosine kinase inhibitors (e.g.: erlotinib).
* Known previous or ongoing abuse of narcotic drug, other medication or alcohol.
* Any investigational agent within 30 days before initiation of study treatment. - Must not have had a major surgical procedure within 28 days of initiation of treatment.
* Subject unwilling or unable to comply with study requirements.