Topotecan, High-Dose Cyclophosphamide, Carboplatin, and an Autologous Peripheral Blood Cell Transplant in Treating Patients With Recurrent Ovarian Cancer or Primary Peritoneal Cancer

DISEASE CHARACTERISTICS:

* Histologically confirmed ovarian epithelial or primary peritoneal cavity cancer

  * Recurrent, relapsed, or persistent disease meeting 1 or more of the following criteria:

    * Patients with a positive second-look laparotomy who are not candidates for higher priority GOG protocols
    * Largest mass of recurrent disease ≤ 0.2 cm achieved by surgery or chemotherapy
    * Achievement of complete response to 1 prior regimen of platinum-based chemotherapy with relapse \> 6 months from last chemotherapy
    * Achievement of partial response to 1 platinum-based chemotherapy regimen prior to study
  * Histological proof of disease recurrence with or without a rising serum CA-125 level (relapsed or recurrent disease)
* The following histological cell types are allowed:

  * Clear-cell adenocarcinoma
  * Endometrioid adenocarcinoma
  * Mixed epithelial carcinoma
  * Mucinous adenocarcinoma
  * Serous adenocarcinoma
  * Undifferentiated carcinoma
* Must have unilateral bone marrow aspirate and biopsy with cytogenetics without evidence of metastatic ovarian carcinoma by conventional morphology within 1 month of registration
* Not eligible for GOG-164

PATIENT CHARACTERISTICS:

* ECOG performance status 0-2
* Creatinine ≤ 1.5 mg/dL
* Total bilirubin ≤ 2.0 mg/dL (≤ 5.0 mg/dL with metastatic disease)
* AST ≤ 2 times upper limit of normal (ULN) (≤ 600 units/mL with metastatic disease)
* Alkaline phosphatase ≤ 2 times ULN (unless related to metastatic disease)
* ANC ≥ 1,000/mm\^3
* Platelets ≥ 100,000/mm\^3
* Cardiac ejection fraction ≥ 45% by rest ECHO or MUGA
* FEV\_1 ≥ 50% of predicted
* HIV negative
* No uncontrolled infection
* No severe medical or psychiatric illness, including any of the following:

  * Renal failure
  * Brittle insulin dependent diabetes mellitus
  * Congestive heart failure
  * History of myocardial infarction within the past 3 months
  * Significant arrhythmia requiring medication
  * Poorly controlled hypertension (diastolic blood pressure \>100 mm Hg)
  * History of hospitalization for severe depression or psychosis
  * Significant non-neoplastic pulmonary disease
  * Current alcohol or drug abuse.
  * Active infection
  * Active peptic ulcer disease
* No prior malignancy within the past 5 years except adequately treated basal cell or squamous cell carcinoma of the skin or in situ cervical carcinoma

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
* No more than 1 prior treatment regimen for this cancer
* More than 3 weeks since surgery
* No prior topotecan hydrochloride