Feasibility of Haploidentical Hematopoietic Stem Cell Transplantation Using CAMPATH-1H

Inclusion Criteria:

INCLUSION CRITERIA - RECIPIENT: (all of the following)

* Ages 5-50 years
* Acute myelogenous leukemia (AML) or acute lymphoblastic leukemia (ALL)
* Second remission (CR2) in standard risk patients or CR1 in cases with high-risk features (poor cytogenetic changes or secondary to myelodysplastic syndrome)
* Unavailability of HLA identical related donor or matched unrelated donor.
* Unavailability of other therapeutic intervention that prolongs patient survival.
* Lack of active infection.
* No history of allergy to CAMPATH.
* For adults: Ability to comprehend the investigational nature of the study and provide informed consent. For minors: Written informed consent from one parent or guardian..
* Social and intellectual competency of the patient and his/her family to follow medical recommendations.

INCLUSION CRITERIA - DONOR:

* The donor must be haploidentical with the recipient: In the order of priority, siblings who have an identical paternal HLA haplotype with the patient, offspring (for female patients that do not have appropriate sibling), and mother.
* Possibly, it is better that the donor and recipient to be of same blood group and sex..
* Possibly, it is better that female donors not to be multiparous.
* Weight greater than or equal to 18 kg.
* Age between 2 and 60 years old.
* For adults: Ability to comprehend the investigational nature of the study and provide informed consent. For minors: Written informed consent from one parent or guardian and informed assent: The process will be explained to the minor on a level of complexity appropriate for their age and ability to comprehend.
* Negative two-way WBC crossmatch with the recipient.

Exclusion Criteria:

EXCLUSION CRITERIA - RECIPIENT: (ANY OF THE FOLLOWING)

* Major anticipated illness or organ failure incompatible with survival from transplantation.
* Severe psychiatric illness. Mental deficiency sufficiently severe as to make compliance with the transplantation procedure unlikely and making informed consent impossible.
* Positive pregnancy test for women of childbearing age.
* HIV positive
* Active infection
* Left ventricular ejection fraction less than 40%
* AST/SGOT greater than 20 x ULN (CTCAE grade IV v3.0)
* Bilirubin greater than 10 x ULN (CTCAE grade IV v3.0)
* Creatinine greater than 6 x ULN (CTCAE grade IV v 3.0)
* Occurrence of allergy symptoms and signs during CAMPATH infusion. EXCLUSION CRITERIA - DONOR: (ANY OF THE FOLLOWING)
* Pregnant or lactating
* Unfit to receive filgrastim (G-CSF) and undergo apheresis (abnormal blood counts, history of stroke, uncontrolled hypertension)
* Sickling hemoglobinopathies including HbSS, HbAS, HbSC
* HBsAg or HIV positive
* Active infection
* CMV positive (for CMV negative recipients)
* Severe psychiatric illness. Mental deficiency sufficiently severe as to make compliance with the BMT treatment unlikely and making informed consent impossible
* Contraindication to general anesthesia.