A Trial of Thalidomide, Celecoxib, Etoposide and Cyclophosphamide in Patients With Relapsed or Progressive Cancer

Inclusion Criteria:

* Patients with relapsed or progressive poor prognosis tumors for which no curative therapy exists.
* Histologic confirmation of disease at diagnosis or relapse.
* Brain stem glioma patients who have progressed after radiation therapy do not require histologic confirmation. Duration of symptoms at the time of diagnosis must be less than 3 months and should consist of cranial nerve deficits and/or ataxia and/or long tract signs.
* Prior radiation therapy and/or chemotherapy are permitted.
* Karnofsky Performance Status \>50. For infants, the Lansky play scale \>50% can be substituted.
* Life expectancy \> 2 months.
* No active uncontrolled cardiac, hepatic, renal, or psychiatric disease defined as ≥ grade 3 based on the common toxicity criteria.
* No known allergies to sulfonamides
* Adequate renal function: Serum Creatinine \< 1.5 mg/dl or creatinine clearance or GFR \> 70 ml/min.
* Adequate hepatic function: Total Bilirubin \< 1.5 mg/dl; SGOT, SGPT, Alk Phos \< 3x normal.(SGOT can be \< 4x normal for patients on Zantac).
* Adequate bone marrow reserve: Hgb \> 9.0 g/dl, Platelets \> 75,000/mm3 (transfusion independent),WBC \> 2000/mm3 and ANC \> 1000/mm3.
* Patients receiving steroids and/or anti-seizure medications are eligible for this study.

Exclusion Criteria:

* Patients must not be pregnant or nursing, and all patients of child bearing age (both male and female) must be willing to practice birth control during and for 2 months after treatment with thalidomide. If the patient is unable to use oral contraceptives for medical reasons, 2 different barrier methods may be used if approved by the treating physician.
* No concurrent use of other investigational agents.
* Patients that have received more than 2 months of oral therapy with any of the agents used in this study will be ineligible. Standard administration of IV etoposide and cyclophosphamide, usually administered in 3-week cycles is permitted.