Clinical trial · Interventional
Ultraviolet-B Light Therapy and Allogeneic Stem Cell Transplantation in Treating Patients With Hematologic Malignancies
Immunomodulation by Ultraviolet B-Irradiation (UVB) to Facilitate Allogeneic Stem Cell Transplantation for Treatment of Hematologic Malignancies
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy. Sometimes the transplanted cells from a donor are rejected by the body's normal cells. Ultraviolet-B light therapy given before and after allogeneic stem cell transplantation may help prevent this from happening. PURPOSE: Clinical trial to study the effectiveness of combining ultraviolet-B light therapy with allogeneic stem cell transplantation in treating patients who have hematologic malignancies.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Myeloproliferative Disorders | Myeloproliferative Neoplasm | ALIAS | 0.90 |
| Leukemia | Leukemia | ONTOLOGY_EXACT | 0.90 |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Multiple Myeloma and Plasma Cell Neoplasm | — | UNRESOLVED | — |
| Myelodysplastic/Myeloproliferative Diseases | Myelodysplastic/Myeloproliferative Neoplasm | ALIAS | 0.90 |
| Myelodysplastic Syndromes | Myelodysplastic Syndrome | ALIAS | 0.90 |
Interventions
Interventions (8)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| allogeneic bone marrow transplantation | Procedure | — | UNRESOLVED |
| anti-thymocyte globulin | Biological | — | UNRESOLVED |
| cyclophosphamide | Drug | Cyclophosphamide | ALIAS |
| cyclosporine | Drug | — | UNRESOLVED |
| fludarabine phosphate | Drug | Fludarabine | ALIAS |
| methylprednisolone | Drug | — | UNRESOLVED |
| peripheral blood stem cell transplantation | Procedure | — | UNRESOLVED |
| UV light therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Study the effectiveness of combining ultraviolet-B light therapy with allogeneic stem cell transplantation in treating patients who have hematologic malignancies.
- timeFrame
- Patients are followed at least monthly for 3 months and then at 6, 12, 18, and 24 months.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS:
* Histologically confirmed diagnosis of any of the following hematologic malignancies:
* Acute myeloid leukemia (AML) meeting any of the following criteria:
* First complete remission with high-risk karyotype
* Translocations t(15;17) allowed only if failed first-line induction therapy OR molecular evidence of persistent disease exists
* Translocations t(8;21) and inv(16) allowed only if failed first-line induction therapy
* Second or subsequent complete remission
* Minimal residual disease\*
* Acute lymphoblastic leukemia meeting any of the following criteria:
* Failed induction therapy and has minimal residual disease\* by salvage therapy
* First complete remission with high-risk karyotype (e.g., t\[4;11\] or t\[9;22\])
* Relapsed disease allowed provided a second or subsequent complete remission or minimal residual disease\* is achieved
* Chronic myelogenous leukemia meeting any of the following criteria:
* Persistent or relapsed disease after 1 year of imatinib mesylate therapy
* Accelerated phase or blast crisis
* Blast crisis allowed after reinduction chemotherapy places disease in chronic phase
* Myelodysplastic syndromes meeting any of the following criteria:
* Refractory to medical management
* Cytogenetic abnormalities predictive of transformation into acute leukemia, including 5q-, 7q-, monosomy 7 and trisomy 8, or evidence of evolution to AML (e.g., refractory anemia with excess blasts (RAEB) or RAEB in transformation)
* Non-Hodgkin's lymphoma or Hodgkin's lymphoma meeting any of the following criteria:
* Beyond first complete remission or failed primary induction therapy and demonstrated sensitivity to therapy during the 6 months before transplantation
* Recurrent disease after autologous stem cell transplantation
* Must be at least 3 months posttransplantation
* Cyclin D1+ mantle cell lymphoma allowed after induction therapy and in first remission
* Multiple myeloma meeting either of the following criteria:
* Refractory or relapsed disease
* Residual disease after autologous transplantation
* Chronic lymphocytic leukemia (CLL) meeting all of the following criteria:
* Peripheral blood absolute lymphocyte count greater than 5,000/mm\^3
* Small to moderate size lymphocytes and less than 55% pro-lymphocytes, atypical lymphocytes, or lymphoblasts morphologically
* B-cell or T-cell
* Myeloproliferative disorders, including myelofibrosis
* Philadelphia negative
* Availability of a HLA-A, B, and DR identical family donor OR HLA-A, B, and DR genetically matched unrelated donor
* Must meet 1 of the following criteria:
* At least 55 years of age at time of transplantation
* Received extensive prior therapy (i.e., more than 1 year of alkylator therapy or more than 2 different prior salvage regimens) or stem cell transplantation with myeloablative conditioning (either autologous or allogeneic)
* Presenting with comorbid condition (e.g., abnormal cardiac, pulmonary, or renal function and/or prior life-threatening infection) that precludes eligibility for enrollment in allogeneic transplantation protocols with full ablation conditioning
* No active CNS disease NOTE: \*Defined as having no circulating blasts, absolute neutrophil count greater than 1,000/mm3 and less than 10% blasts in bone marrow at least 3 weeks after last systemic chemotherapy
PATIENT CHARACTERISTICS:
Age
* See Disease Characteristics
* Over 18
Performance status
* ECOG 0-2
Life expectancy
* At least 3 months
Hematopoietic
* See Disease Characteristics
Hepatic
* Bilirubin no greater than 2.0 mg/dL
* ALT/AST no greater than 4 times normal
Renal
* See Disease Characteristics
* Creatinine less than 2.0 mg/dL OR
* Creatinine clearance at least 50 mL/min
Cardiovascular
* See Disease Characteristics
* Normal cardiac function by echocardiogram or radionuclide scan
* Shortening fraction or ejection fraction at least 40% of normal
Pulmonary
* See Disease Characteristics
* DLCO at least 60%
* FEV\_1 greater than 50% of predicted
* Pulse oximetry greater than 85%
Other
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* HIV negative
* No uncontrolled active infection
PRIOR CONCURRENT THERAPY:
Biologic therapy
* See Disease Characteristics
* At least 2 weeks since prior biologic response modifiers, signal transduction inhibitors, or monoclonal antibodies
Chemotherapy
* See Disease Characteristics
* At least 4 weeks since prior systemic conventional chemotherapy
Endocrine therapy
* Not specified
Radiotherapy
* Not specified
Surgery
* Not specified
Other
* Recovered from prior therapy
* No concurrent sun block/sunscreen or any cosmetic that may act as a sunscreen (e.g., lotion with SPF) on the days of scheduled ultraviolet-B light therapyReferences
Publications (0)
Data not yet available