Combination Chemotherapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Myeloproliferative Disorders

DISEASE CHARACTERISTICS:

* Idiopathic myelofibrosis (IMF) with at least 1 poor prognosis characteristic, including but not limited to:

  * Hemoglobin less than 10 g/dL
  * Platelet count less than 100,000/mm\^3
  * Hepatomegaly (i.e., palpable liver edge 5 cm below costal margin)
  * Clinical requirement for splenectomy
* Other myeloproliferative disorders in an IMF like myelofibrotic state eligible
* No evidence of leukemic progression, e.g.:

  * Greater than 15% peripheral blood blasts
  * Fever or bone pain of unknown origin
  * Rapidly progressing splenomegaly
* No other causes for myelofibrosis, such as:

  * Collagen vascular disorder
  * Lymphoma
  * Granulomatous infection
  * Metastatic carcinoma
  * Hairy cell leukemia
  * Myelodysplastic syndrome
* No active central nervous system disease
* One of the following donor/patient pairings is required:

  * Donor status:

    * Genotypic or phenotypic HLA-matched relative

      * Maximum patient age of 65
    * One antigen HLA-mismatched relative, HLA-matched unrelated donor, or one antigen HLA-mismatched unrelated donor

      * Maximum patient age of 55
* Transplant on this protocol allowed for patients registered on protocol FHCRC-1106.00

PATIENT CHARACTERISTICS:

Age:

* 65 and under

Performance status:

* Not specified

Hematopoietic:

* See Disease Characteristics

Hepatic:

* Bilirubin no greater than 2 times normal
* SGPT no greater than 4 times normal

Renal:

* Creatinine no greater than two times normal OR
* Creatinine clearance at least 50%

Cardiovascular:

* Ejection fraction at least 50%
* Cardiac evaluation required if signs or symptoms of coronary artery disease or congestive heart failure

Other:

* HIV negative
* No active infection
* Patients excluded from this protocol are referred to protocol FHCRC-179.05

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* Not specified

Chemotherapy:

* Not specified

Endocrine therapy:

* Not specified

Radiotherapy:

* Not specified

Surgery:

* Not specified