Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Hodgkin's Lymphoma

DISEASE CHARACTERISTICS:

* Histologically proven stage I-IV Hodgkin's lymphoma
* Must have refractory or relapsed disease, defined by 1 of the following:

  * Failure to achieve a complete remission (CR) after 4 courses of conventional-dose front-line chemotherapy
  * Disease in second or greater remission

    * Patients should be encouraged to undergo transplantation prior to a third salvage regimen
    * Patients previously treated with multiple regimens considered on a case-by-case basis
* No chemoresistant disease, defined as active progression with tumor growth greater than 25% by volume during first-line chemotherapy

  * Patients who respond to second-line chemotherapy may be eligible
* Stable residual masses after conventional-dose chemotherapy not considered treatment failures

  * Active (refractory or relapsed) disease must be proven histologically or documented by gallium nitrate uptake
* Syngeneic marrow transplantation offered to patients with consenting identical twin donor
* No CNS involvement by lymphoma

PATIENT CHARACTERISTICS:

Age:

* 15 to 60 (selected patients up to age 70 may be eligible)

Performance status:

* ECOG 0-2

Life expectancy:

* Not specified

Hematopoietic:

* WBC greater than 4,000/mm\^3
* Absolute neutrophil count greater than 2,000/mm\^3
* Platelet count greater than 100,000/mm\^3

Hepatic:

* Bilirubin less than 2.0 mg/dL
* SGOT and SGPT less than 2 times upper limit of normal
* Albumin greater than 3.0 g/dL

Renal:

* Must meet 1 of the following criteria:

  * Creatinine less than 1.8 mg/dL
  * Creatinine clearance greater than 60 mL/min
  * BUN less than 20 mg/dL

Cardiovascular:

* Left ventricular ejection fraction at least 50%

Pulmonary:

* DLCO, FEV\_1, and FVC greater than 50% of predicted OR
* Resting pO\_2 greater than 70 mm Hg on room air

Other:

* HIV negative
* No severe neurologic or emotional disorders
* No active infection
* No other disease that would limit life expectancy
* Not pregnant
* Fertile patients must use effective contraception
* Adequate psychosocial support required

PRIOR CONCURRENT THERAPY:

Biologic therapy

* Not specified

Chemotherapy

* See Disease Characteristics

Endocrine therapy

* Not specified

Radiotherapy

* Not specified

Surgery

* Not specified