Combination Chemotherapy and Bone Marrow Transplant in Treating Patients With Refractory or Recurrent Ovarian Cancer

DISEASE CHARACTERISTICS:

* Diagnosis of refractory or relapsed ovarian epithelial cancer

  * Must have failed prior regimen containing cisplatin or carboplatin
* Bidimensionally measurable or evaluable disease

  * Serial CA-125 antigen titers or cytologically positive pleural effusion and/or ascites acceptable as evaluable disease
* Autologous bone marrow harvest of greater than 1.2 x 10 to the eighth nucleated cells/kg required before study entry
* No evidence of tumor at marrow harvest sites by bilateral bone marrow aspirates and biopsies, pelvic x-ray, and bone scan
* CNS involvement allowed

PATIENT CHARACTERISTICS:

Age:

* Under 65

Performance status:

* SWOG 0-2

Life expectancy:

* At least 8 weeks

Hematopoietic:

* WBC greater than 3,500/mm\^3
* Platelet count greater than 100,000/mm\^3
* Hemoglobin greater than 10.0 g/dL

Hepatic:

* Bilirubin less than 2.0 mg/dL
* SGOT and SGPT less than 2 times upper limit of normal

Renal:

* Creatinine clearance greater than 60 mL/min
* No prior hemorrhagic cystitis

Cardiovascular:

* LVEF greater than 45% by MUGA scan

Other:

* No hearing loss in voice tones
* No active infection
* No psychological contraindication to study treatment
* Not pregnant
* Negative pregnancy test
* HIV negative
* General medical condition must allow general anesthesia

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* See Disease Characteristics
* No prior bone marrow transplantation
* More than 4 weeks since other prior biologic therapy and recovered

Chemotherapy:

* See Disease Characteristics
* More than 4 weeks since prior chemotherapy (at least 6 weeks for nitrosoureas or mitomycin) and recovered

Endocrine therapy:

* Not specified

Radiotherapy:

* More than 4 weeks since prior radiotherapy and recovered

Surgery:

* Not specified