Clinical trial · Interventional
Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer
Women's Health Study of Low-dose Aspirin and Vitamin E in Apparently Healthy Women
NCT00000479CI-TRIAL-00007202WHScompletedPhase 3Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate the effects of low-dose aspirin and vitamin E in primary prevention of cardiovascular disease and cancer in apparently healthy women.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiovascular Diseases | — | UNRESOLVED | — |
| Cerebrovascular Disorders | — | UNRESOLVED | — |
| Coronary Disease | — | UNRESOLVED | — |
| Heart Diseases | — | UNRESOLVED | — |
| Myocardial Infarction | — | UNRESOLVED | — |
| Myocardial Ischemia | — | UNRESOLVED | — |
| Vascular Diseases | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Aspirin | Drug | Aspirin | ALIAS |
| Placebo | Behavioral | — | UNRESOLVED |
| Vitamin E | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- 1
- description
- Vitamin E (600 IU every other day) and aspirin (100 mg every other day)
- interventionNames
- Drug: Aspirin
- Drug: Vitamin E
- type
- EXPERIMENTAL
- label
- 2
- description
- Vitamin E (600 IU every other day) and placebo
- interventionNames
- Drug: Vitamin E
- Behavioral: Placebo
- type
- EXPERIMENTAL
- label
- 3
- description
- Aspirin (100 mg every other day) and placebo
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Healthy women * No previous history of cardiovascular disease or cancer * No contraindications to aspirin or vitamin E
References
Publications (137)
- BACKGROUNDRidker PM, Miletich JP, Hennekens CH, Buring JE. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA. 1997 Apr 23-30;277(16):1305-7. PMID 9109469
- BACKGROUNDRidker PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation. 1998 Aug 25;98(8):731-3. doi: 10.1161/01.cir.98.8.731. PMID 9727541
- BACKGROUNDRidker PM, Hennekens CH, Rifai N, Buring JE, Manson JE. Hormone replacement therapy and increased plasma concentration of C-reactive protein. Circulation. 1999 Aug 17;100(7):713-6. doi: 10.1161/01.cir.100.7.713. PMID 10449692
- BACKGROUNDLee IM, Cook NR, Manson JE, Buring JE, Hennekens CH. Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study. J Natl Cancer Inst. 1999 Dec 15;91(24):2102-6. doi: 10.1093/jnci/91.24.2102. PMID 10601381
- BACKGROUNDRexrode KM, Lee IM, Cook NR, Hennekens CH, Buring JE. Baseline characteristics of participants in the Women's Health Study. J Womens Health Gend Based Med. 2000 Jan-Feb;9(1):19-27. doi: 10.1089/152460900318911. PMID 10718501
- BACKGROUNDLiu S, Manson JE, Lee IM, Cole SR, Hennekens CH, Willett WC, Buring JE. Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study. Am J Clin Nutr. 2000 Oct;72(4):922-8. doi: 10.1093/ajcn/72.4.922. PMID 11010932
- BACKGROUNDLee IM, Rexrode KM, Cook NR, Manson JE, Buring JE. Physical activity and coronary heart disease in women: is "no pain, no gain" passe? JAMA. 2001 Mar 21;285(11):1447-54. doi: 10.1001/jama.285.11.1447. PMID 11255420