Ranking · Unmet Need

Active trials per 1,000 annual deaths

Active interventional studies divided by annual deaths (thousands) in the same population scope. A burden-normalized measure of clinical-research intensity; it depends on the epidemiology source of the scope and on how registrants phrase conditions.

Computedci-trials-per-deaths-v1unit: per 1,000 deathshigher = betterAll metrics

Rank	Δ	Cancer	Active trials per 1,000 annual deaths (per 1,000 deaths)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Nasopharyngeal Neoplasm	393.1	100	Medium confidence	cdc-wonder clinicaltrials	inputs deaths 664 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 261 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9070 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580266
2	=	Hodgkin Lymphoma	196.9	97.1	Medium confidence	cdc-wonder clinicaltrials	inputs deaths 909 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 179 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10891 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580267
3	=	Malignant Cervical Neoplasm	120	94.1	High confidence	cdc-wonder clinicaltrials	inputs deaths 4207 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 505 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10261 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580268
4	=	Non-Hodgkin Lymphoma	109	91.2	High confidence	cdc-wonder clinicaltrials	inputs deaths 19882 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 2168 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10954 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580269
5	=	Malignant Hypopharyngeal Neoplasm	106.4	88.2	Medium confidence	cdc-wonder clinicaltrials	inputs deaths 498 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 53 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9133 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580270
6	=	Malignant Penile Neoplasm	103.6	85.3	Medium confidence	cdc-wonder clinicaltrials	inputs deaths 415 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 43 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10450 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580271
7	=	Malignant Testicular Neoplasm	93.1	82.4	Medium confidence	cdc-wonder clinicaltrials	inputs deaths 462 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 43 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10576 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580272
8	=	Malignant Thyroid Gland Neoplasm	79	79.4	High confidence	cdc-wonder clinicaltrials	inputs deaths 2229 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 176 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10828 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580273
9	=	Leukemia	74.5	76.5	High confidence	cdc-wonder clinicaltrials	inputs deaths 23740 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 1769 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 11080 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580274
10	=	Malignant Vaginal Neoplasm	71.3	73.5	Medium confidence	cdc-wonder clinicaltrials	inputs deaths 435 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 31 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10198 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580275
11	=	Multiple Myeloma	68	70.6	High confidence	cdc-wonder clinicaltrials	inputs deaths 11967 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 814 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 11017 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580276
12	=	Malignant Breast Neoplasm	59.8	67.6	High confidence	cdc-wonder clinicaltrials	inputs deaths 43897 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 2627 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10072 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580277
13	=	Malignant Gastric Neoplasm	58	64.7	High confidence	cdc-wonder clinicaltrials	inputs deaths 11246 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 652 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9259 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580278
14	=	Malignant Ovarian Neoplasm	54.1	61.8	High confidence	cdc-wonder clinicaltrials	inputs deaths 12654 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 684 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10387 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580279
15	=	Malignant Salivary Gland Neoplasm	53.7	58.8	High confidence	cdc-wonder clinicaltrials	inputs deaths 1173 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 63 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 8944 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580280
16	=	Malignant Uterine Corpus Neoplasm	47.7	55.9	High confidence	cdc-wonder clinicaltrials	inputs deaths 8608 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 411 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10324 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580281
17	=	Malignant Mesothelioma	45.4	52.9	High confidence	cdc-wonder clinicaltrials	inputs deaths 2114 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 96 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9952 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580282
18	=	Malignant Central Nervous System Neoplasm	44.4	50	High confidence	cdc-wonder clinicaltrials	inputs deaths 18523 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 823 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10765 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580283
19	=	Malignant Oropharyngeal Neoplasm	43.5	47.1	High confidence	cdc-wonder clinicaltrials	inputs deaths 3286 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 143 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9007 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580284
20	=	Malignant Anal Neoplasm	41.2	44.1	High confidence	cdc-wonder clinicaltrials	inputs deaths 1651 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 68 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9448 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580285
21	=	Malignant Prostate Neoplasm	39.5	41.2	High confidence	cdc-wonder clinicaltrials	inputs deaths 34815 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 1375 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10513 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580286
22	=	Malignant Vulvar Neoplasm	34.7	38.2	High confidence	cdc-wonder clinicaltrials	inputs deaths 1555 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 54 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10135 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580287
23	=	Malignant Esophageal Neoplasm	31.8	35.3	High confidence	cdc-wonder clinicaltrials	inputs deaths 16274 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 518 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9196 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580288
24	=	Malignant Kidney Neoplasm	29.8	32.4	High confidence	cdc-wonder clinicaltrials	inputs deaths 15215 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 453 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10639 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580289
25	=	Malignant Liver Neoplasm	29.7	29.4	High confidence	cdc-wonder clinicaltrials	inputs deaths 30532 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 906 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9511 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580290
26	=	Malignant Rectal Neoplasm	28.7	26.5	High confidence	cdc-wonder clinicaltrials	inputs deaths 13446 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 386 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9385 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580291
27	=	Malignant Lip and Oral Cavity Neoplasm	27.5	23.5	High confidence	cdc-wonder clinicaltrials	inputs deaths 5424 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 149 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 8881 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580292
28	=	Skin Carcinoma	23.3	20.6	High confidence	cdc-wonder clinicaltrials	inputs deaths 5462 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 127 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9889 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580293
29	=	Malignant Lung Neoplasm	20.5	17.6	High confidence	cdc-wonder clinicaltrials	inputs deaths 128762 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 2644 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9763 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580294
30	=	Malignant Bladder Neoplasm	19.9	14.7	High confidence	cdc-wonder clinicaltrials	inputs deaths 17396 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 346 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 10702 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580295
31	=	Malignant Pancreatic Neoplasm	17.6	11.8	High confidence	cdc-wonder clinicaltrials	inputs deaths 51327 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 904 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9637 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580296
32	=	Malignant Laryngeal Neoplasm	16.1	8.8	High confidence	cdc-wonder clinicaltrials	inputs deaths 4095 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 66 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9700 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580297
33	=	Cutaneous Melanoma	9	5.9	High confidence	cdc-wonder clinicaltrials	inputs deaths 8671 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 78 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9826 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580298
34	=	Malignant Gallbladder Neoplasm	7.3	2.9	High confidence	cdc-wonder clinicaltrials	inputs deaths 4402 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 32 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9574 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580299
35	=	Malignant Colon Neoplasm	5.5	0	High confidence	cdc-wonder clinicaltrials	inputs deaths 40801 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 225 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9322 componentsFormulaVersion ci-research-gap-components-v1 ranking row 2580300

Data updated 17 hours agoSource updated unknown35 eligible entities · inputs hash 9550c89acf4e1815462736d8

Methodology

How this table was built

Formula: active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)
Version: ci-trials-per-deaths-v1
Scope: USA · both sexes · all ages · 2024 · top-level cancers
Scope key: geo=USA|sex=all|age=all|year=2024|level=top
Eligible entities: 35
Generated: Sep 29, 2026, 06:16 AM UTC
Inputs hash: 9550c89acf4e1815462736d8
Sources: CDC WONDER — Underlying Cause of Death (US mortality by ICD-10 site)ClinicalTrials.gov
Aggregation: none

Eligibility

requires: mortality_count
active_trials
minDeaths: 100
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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