Publication
Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerMalignant Breast Neoplasmcivic_curation1.00
- drugDoxorubicincivic_curation1.00
- geneTP53civic_curation1.00
- variantTP53 Mutationcivic_curation1.00
- variantTP53 R248Qcivic_curation1.00
- variantTP53 R249civic_curation1.00
- variantTP53 R273Ccivic_curation1.00
- variantTP53 R273Hcivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 9569050
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 Mutation1 | ||||||||
| (prognostic) | Malignant Breast Neoplasm | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID393In breast cancer patients harboring TP53 mutation, mutations in conserved regions such as R249 are prognostic for a worse overall survival compared to those harboring wild-type TP53. Multivariate Cox … (full text at CIViC) PMID 9569050 · Berns et al., 1998 · Open in CIViC | civic |
| TP53 R248Q1 | ||||||||
| (prognostic) | Malignant Breast Neoplasm | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID391In breast cancer patients harboring TP53 mutation, mutations in DNA contact regions such as R248 (N=10, 6 at R248) are prognostic for a worse relapse-free survival compared to other non-silent mutatio… (full text at CIViC) PMID 9569050 · Berns et al., 1998 · Open in CIViC | civic |
| TP53 R2491 | ||||||||
| Doxorubicin | Malignant Breast Neoplasm | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID399Breast tumors with R175H or R249 mutations are more responsive to doxorubicin than breast tumors with wild type TP53. PMID 9569050 · Berns et al., 1998 · Open in CIViC | civic |
| TP53 R273C1 | ||||||||
| (prognostic) | Malignant Breast Neoplasm | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID396In breast cancer patients harboring TP53 mutation, mutations in DNA contact regions such as R273 are prognostic for a worse relapse-free survival compared to other non-silent mutations in TP53. PMID 9569050 · Berns et al., 1998 · Open in CIViC | civic |
| TP53 R273H1 | ||||||||
| (prognostic) | Malignant Breast Neoplasm | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID398In breast cancer patients harboring TP53 mutation, mutations in DNA contact regions such as R273 are prognostic for a worse relapse-free survival compared to other non-silent mutations in TP53. PMID 9569050 · Berns et al., 1998 · Open in CIViC | civic |