Publication
The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.
Authors not recorded
Blood1995PMID 7780150stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerB Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1civic_curation1.00
- drugNot Applicablecivic_curation1.00
- geneRUNX1civic_curation1.00
- variantRUNX1 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 7780150
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RUNX1 Fusion1 | ||||||||
| Not Applicable | B Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1ALIAS | Predictive | B | Supports Adverse Response | 4 | accepted | EID12374In this study, the authors characterized the TEL (currently ETV6)::AML1 (currently RUNX1) gene fusion in B-lymphoblastic leukemia (B-ALL) with the t(12;21)(p12;q22) using cytogenetic and molecular met… (full text at CIViC) PMID 7780150 · Romana et al., 1995 · Open in CIViC | civic |