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Patient-derived mesenchymal stromal cells establish an IL-6 axis that marks progression from smouldering to active multiple myeloma.

Phoebe Elizabeth Blair, Tianyuan Chu, Andrew Robinson, Khalid Saja, Stuart Rushworth, Ralf Michael Zwacka, Andrea Mohr

CytokineNov 1, 2026PMID 42721887doi:10.1016/j.cyto.2026.157213 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

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IL-6 signalling in the bone marrow (BM) is compartmentalised. Different cell populations within the BM niche contribute distinct components of the IL-6 signalling network, yet how their roles change during myeloma progression has remained unclear. We examined how the respective contributions of…

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