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Machine Learning-Derived Immune Gene Signature Predicts Prognosis and Therapeutic Vulnerabilities in Multiple Myeloma.

Kai Wang, Chenfei Zhao, Jingru Shi, Shiwei Liu, Yi Chen, Jujuan Wang, Zhengxu Sun, Sanmei Wang, Lei Fan, Jin Fan, Xiaoyan Qu

Cancer scienceSep 6, 2026PMID 42702361doi:10.1111/cas.70523 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000002
Published

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The immune microenvironment contributes substantially to the biological and clinical heterogeneity of multiple myeloma (MM), yet immune-related molecular biomarkers with reproducible prognostic value remain limited. Here, we developed a 12-gene immune-related gene signature (IRGS) using an…

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