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SEI1 complex silences p53 to drive myeloma progression.

Rui Chen, Rui Liu, Zhihong Fang, Daoyan Yang, Zou Li, Yuan Li, Yuan Li, Shurong Liu, Qi Liu, Yanqi Chao, Chong Wang, Huan Liu

iScienceSep 18, 2026PMID 42698665doi:10.1016/j.isci.2026.117300 PMC13542490Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000002
Published

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SEI1 is overexpressed in multiple myeloma and correlates with poor prognosis. In this study, we identify SEI1 as a crucial driver of myeloma pathogenesis through a previously unrecognized mechanism: transcriptional inactivation of the tumor suppressor p53. Mechanistically, SEI1 forms a…

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