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CD200 is a potent new growth factor in Multiple Myeloma dependent on IGF1 receptor signaling.

Angélique Bruyer, Nicolas Robert, Jules Varbedian, Elvira Garcia De Paco, Lauryn Jaffory, Stéphanie Boireau, Christophe Hirtz, Jérôme Vialaret, Pierre Martineau, Bruno Robert, Guilhem Requirand, Guillaume Cartron, Laure Vincent, Charles Herbaux, Jérôme Moreaux, Caroline Bret

Translational oncologyOct 1, 2026PMID 42664786doi:10.1016/j.tranon.2026.103000 PMC13545282Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 8, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260908-000002
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CD200 is an immune checkpoint aberrantly expressed in 70% of newly diagnosed patients with multiple myeloma (MM) and associated with a poor outcome. CD200 expression by tumor cells inhibits immune response through interaction with CD200R and participates in resistance to immune based therapies.…

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