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Single-cell and bulk transcriptomic profiling of M2-like tumor-associated macrophages reveals a prognostic signature and an inflammation-metabolism crosstalk program in multiple myeloma.

Hui Zhao, Jing Kang, Huiling Ouyang, Xiaye Lv, Ziying Huang, Bingni Zhao, Kai Wang

Translational oncologyOct 1, 2026PMID 42636658doi:10.1016/j.tranon.2026.102983 PMC13542500Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260908-000002
Published

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BACKGROUND: M2-like tumor-associated macrophages (TAMs) contribute to multiple myeloma (MM) progression and treatment resistance, yet their internal heterogeneity remains poorly understood. We used single-cell RNA sequencing (scRNA-seq) with bulk transcriptomic cohorts to resolve MM-specific M2-TAM…

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