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Mosunetuzumab With Response-Adapted Polatuzumab Vedotin and Obinutuzumab in Untreated Indolent B-Cell Non-Hodgkin Lymphoma.

Ryan C Lynch, Christina Poh, Mazyar Shadman, Brian G Till, Mengyang Di, Chaitra S Ujjani, Vikram Raghunathan, Stephen D Smith, David Maloney, Daria Gausman, Heather Rasmussen, David A Russler-Germain, Todd A Fehniger, David M Kurtz, Ash Alizadeh, Jenna Voutsinas, Ajay K Gopal

Journal of clinical oncology : official journal of the American Society of Clinical OncologySep 20, 2026PMID 42600120doi:10.1200/JCO-25-02906 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

Abstract

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PURPOSE: Chemoimmunotherapy has been the standard approach for untreated indolent B-cell lymphoma. We hypothesized that initial use of the CD3/CD20 bispecific mosunetuzumab followed by response-adapted polatuzumab vedotin and obinutuzumab would yield an optimized chemotherapy-free…

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Registered trialsNCT05169658

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