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Methylation variability and LINE-1 transcriptional activation in multiple myeloma.

Qianhui Wan, Amy Leung, Mahek Vinod Bhandari, Hiroyuki Kato, Joo Y Song, Dustin E Schones

Genome researchSep 1, 2026PMID 42469014doi:10.1101/gr.281420.125 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 15, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260915-000001
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Multiple myeloma (MM) is a type of hematological cancer that arises from uncontrolled proliferation of plasma cells. In addition to frequent genetic mutations, malignant plasma cells are characterized by alterations to the epigenome. Myeloma cells display a genome-wide loss of DNA methylation and a…

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