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The development of novel chimeric antigen receptor gamma-delta T cells against multiple myeloma and single-cell RNA sequencing analysis.

Yang Hong, Cuiling Zhang, Jue Wang, Jianhua Zhang, Yuanyuan Zhu, Yage Zhang, Bang Shao, Yongkun Yang, Taochao Tan, Peipei Xu, Bing Chen

British journal of haematologySep 1, 2026PMID 42438316doi:10.1111/bjh.70660 PMC13570210Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 14, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260914-000001
Published

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Chimeric antigen receptor (CAR) gamma-delta (γδ) T cells offer a major histocompatibility complex-independent, off-the-shelf alternative to conventional CAR alpha-beta (αβ) Tcells, but their efficacy in multiple myeloma (MM) remains underexplored. In this work, we developed a series of novel CAR γδ…

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