Publication
NSD2 degradation remediates the oncogenic cistrome in t(4;14) multiple myeloma.
Bo Hu, Jacob T Edwards, Hardik Modi, Jim Gamez, Oscar Echeagaray, Kyle Hess, Yue Ren, Diana Anderson, Marta Larrayoz, Jinyi Zhu, Scott Johnson, Gauri Deb, Diana Jankeel, Preethi Janardhanan, Jim Leisten, Sophie Peng, Andy Christoforou, Nicholas Stong, Celia Fontanillo, Chad C Bjorklund, Patrick R Hagner, Anita K Gandhi, Jose A Martinez-Climent, Rama Krishna Narla, Antonia Lopez-Girona, Mark Rolfe, Neil Bence, Deborah S Mortensen, Lynda Groocock
- Source
- PubMed
- Retrieved
- Sep 30, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260930-000001
Abstract
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The t(4;14) chromosomal translocation drives overexpression of the histone methyltransferase NSD2 and defines a high-risk segment of patients with multiple myeloma (MM). Herein, we report the discovery of NSD2-ligand-directed degrader (NSD2-LDD), a cereblon-recruiting and PWWP1-mediated LDD that…
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- cancerMultiple Myelomadictionary0.60
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