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NHE6-driven endosome-autophagy axis confers proteasome inhibitor resistance in multiple myeloma.

Liuting Chen, Feifei Cheng, Yung-Hsing Huang, Yutong Wang, Jin He, Jiaqi Liu, Zhiming Wang, Pei Lin, Yihui Fan, Li Bao, Qing Yi, Jing Yang

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapySep 1, 2026PMID 42349083doi:10.1016/j.drup.2026.101436 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 13, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260913-000001
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AIMS: Proteasome inhibitors (PIs) play a central role in multiple myeloma (MM) therapy; however, a substantial proportion of patients fail to achieve durable responses, resulting in early disease progression and limited long-term clinical benefit. This paper aims to understand the molecular…

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