Publication
Product-intrinsic NF-κB-driven transcriptional programs connote durability of CAR-T response in multiple myeloma.
Jerald D Noble, Barbara C Peixoto, Meghan A Menges, Julieta Abraham-Miranda, Constanza Savid-Frontera, William Sawyer, Vasu D Sorathia, Luis A Cuadrado Delgado, Salvatore A Corallo, Julia C Llanos, Emily C Merritt, Gabe de Avila, Omar A Castaneda Puglianini, Hien Liu, Melissa Alsina, Taiga Nishihori, Kenneth H Shain, Ariosto S Silva, Rachid C Baz, Brandon J Blue, Ariel F Grajales-Cruz, Doris K Hansen, John L Cleveland, Fabiana Perna, Conor C Lynch, Jennifer M Binning, Reginald M Atkins, Xiaofei Song, Frederick L Locke, Ciara L Freeman
- Source
- PubMed
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260929-000001
Abstract
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Idecabtagene vicleucel (ide-cel) induces deep responses in relapsed/refractory multiple myeloma, yet more than half of patients relapse within 1 year. The intrinsic features of chimeric antigen receptor T-cell (CAR-T) products that distinguish durable from nondurable responders are poorly defined,…
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Candidate 1
- cancerMultiple Myelomadictionary0.60
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