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Arlocabtagene autoleucel: a GPRC5D-targeted CAR T-cell therapy for heavily pretreated relapsed/refractory multiple myeloma.

Susan Bal, Myo Htut, Omar Nadeem, Larry D Anderson, Tara Gregory, Mehmet Hakan Koçoğlu, Adriana C Rossi, Tom Martin, Daniel N Egan, Luciano J Costa, Hongxiang Hu, Jinjie Chen, Shaoyi Li, Lisa M Kelly, Naomey Sarkis, Safiyyah Ziyad, Kristina M Jordahl, Wei-Ming Kao, Allison J Kaeding, Michael R Burgess, Jesus G Berdeja

BloodSep 3, 2026PMID 42233419doi:10.1182/blood.2025030750 PMC13598863Journal ArticleClinical Trial, Phase IMulticenter StudypubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

Abstract

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Patients with relapsed/refractory multiple myeloma (RRMM) have limited treatment options. Arlocabtagene autoleucel (arlo-cel; BMS-986393) is an autologous chimeric antigen receptor (CAR) T-cell therapy targeting G protein-coupled receptor class C group 5 member D (GPRC5D). This phase 1,…

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Registered trialsNCT04674813

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