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Safety and efficacy of allogeneic CD19-directed CAR-T therapy CTX110 in relapsed/refractory B-cell non-Hodgkin lymphoma.

Joseph P McGuirk, Armin Ghobadi, Carlos R Bachier, Paul J Shaughnessy, Farrukh Awan, Joseph E Maakaron, Michael R Bishop, P Joy Ho, Constantine S Tam, Michael Dickinson, Justin M Darrah, Edmund K Waller, Hemant S Murthy, Ainsley Ross, Leah M Williams, Chenyi Pan, William N Stevens, Laura Serwer, Thao Nguyen, Jonathan Terrett, Demetrios Kalaitzidis, Anna Ma, Huansheng Xu, Mark Benton, Annie Weaver, Sarah Beaussant Cohen, Richard T Maziarz, Chan Cheah

Blood advancesSep 8, 2026PMID 42085626doi:10.1182/bloodadvances.2026020123 PMC13528358Journal ArticleClinical Trial, Phase IMulticenter StudyClinical Trial, Phase IIpubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

Abstract

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This multicenter, single-arm, phase 1/2 study evaluated the safety and efficacy of CD19-directed allogeneic chimeric antigen receptor (CAR) immunotherapy CTX110 in adult patients with relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL). Patients received 1 or 2 treatment courses: standard…

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Validated 1

Candidate 2

Registered trialsNCT04035434

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