Publication
Sustained IL-15 release enhances CAR-T therapy in multiple myeloma via FOXO1 signaling axis activation.
Kuai Yu, Yunxin Zeng, Bo Lu, Mei Xie, Yaqun Wang, Tiantian Sun, Xiaojun Xu, Yuanbin Song, Wei Xiao
BiomaterialsOct 1, 2026PMID 41936184doi:10.1016/j.biomaterials.2026.124187 Journal ArticlepubmedProvenance
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- Oct 1, 2026
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- ING-PUBMED-20261001-000001
Abstract
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This study developed a hypoxia-responsive N-803 nanogel (BiA-N-803 NG) for controlled release of an IL-15 superagonist to enhance CAR-T cell therapy in multiple myeloma. The nanogel was dual-targeted to CD138 and TIM-3 and exhibited stable, hypoxia-triggered release properties. In vitro analyses…
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- cancerMultiple Myelomadictionary0.60
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