Publication
TMB as a predictive biomarker for ICI response in TNBC: current evidence and future directions for augmented anti-tumor responses.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 10, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260910-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerTriple-Negative Breast Carcinomacivic_curation1.00
- drugImmune Checkpoint Inhibitorcivic_curation1.00
- variantHighcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 41249701
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| High2 | ||||||||
| Immune Checkpoint Inhibitor | Triple-Negative Breast CarcinomaALIAS | Predictive | E | Supports N/A | 3 | submitted | EID12950This review synthesizes current preclinical, translational, and clinical evidence evaluating tumor mutational burden (TMB) as a predictive biomarker for immune checkpoint inhibitor (ICI) response in t… (full text at CIViC) PMID 41249701 · Das et al., 2025 · Open in CIViC | civic |
| 〃 | Triple-Negative Breast CarcinomaALIAS | Predictive | E | Supports Sensitivity Response | 2 | accepted | EID13213TMB is being investigated as a predictive biomarker for response to immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC). TMB is defined as the number of somatic mutations per m… (full text at CIViC) PMID 41249701 · Das et al., 2025 · Open in CIViC | civic |