Skip to content
CancerIndex

Publication

Phase II Dose-Randomized Study of Sunvozertinib in Platinum-Pretreated Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor Exon 20 Insertion Mutations (WU-KONG1B).

Authors not recorded

J Clin Oncol2025PMID 40923280stubpubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-CIVIC-20260908-000001
Published

Abstract

Abstract (excerpt)

Only the opening of the abstract is shown; abstract text may carry publisher copyright.

Data not yet available

No abstract stored. Read on PubMed

Linked entities

Linked entities (51)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 51

Curated evidence

Evidence citing this paper (7)

civicProvenance
Source
CIViC — Clinical Interpretation of Variants in Cancer
Dataset
CIViC evidence items
Version
civic-2026-09-08
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Evidence
expert curation
License
CC0 1.0
PMID
40923280
Run
ING-CIVIC-20260908-000001
Open at source
CuratedShowing 1–7 of 7 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.
TherapyCancerTypeLevelDirection · significanceRating (1–5)StatusEvidenceSource
EGFR A767_S768insTLA + EGFR D770delinsAS + EGFR D770delinsGY + EGFR D770_N771insY + EGFR H773_V774insGNPH + EGFR N771_P772insT + EGFR S768_V769insLDS + EGFR V769_D770insCV + EGFR V769_D770insGA + EGFR V769_D770insGVASV1
SunvozertinibLung Non-Small Cell CarcinomaCURATED_BROADERPredictiveASupports Sensitivity Response4accepted
EID12631

In a multinational open label phase II dose randomized study of sunvozertinib in platinum pretreated advanced NSCLC with EGFR exon 20 insertion mutations (WU-KONG1B, NCT03974022; efficacy n = 85 for 2… (full text at CIViC)

PMID 40923280 · Yang et al., 2025 · Open in CIViC

civic
EGFR D770_N771insD + EGFR D770_N771insF + EGFR D770_N771insGD + EGFR D770_N771insGT + EGFR D770_N771insT + EGFR N771delinsCH + EGFR N771delinsGF + EGFR N771delinsRD + EGFR N771delinsSQRGH + EGFR N771_P772insDN1
SunvozertinibLung Non-Small Cell CarcinomaCURATED_BROADERPredictiveASupports Sensitivity Response4accepted
EID12632

In a multinational open label phase II dose randomized study of sunvozertinib in platinum pretreated advanced NSCLC with EGFR exon 20 insertion mutations (WU-KONG1B, NCT03974022; efficacy n = 85 for 2… (full text at CIViC)

PMID 40923280 · Yang et al., 2025 · Open in CIViC

civic
EGFR Exon 20 Insertion1
SunvozertinibLung Non-Small Cell CarcinomaCURATED_BROADERPredictiveASupports Sensitivity Response4accepted
EID12718

In a multinational open label phase II dose randomized study of sunvozertinib in platinum pretreated advanced NSCLC with EGFR exon 20 insertion mutations (WU-KONG1B, NCT03974022; efficacy n = 85 for 2… (full text at CIViC)

PMID 40923280 · Yang et al., 2025 · Open in CIViC

civic
EGFR C775_R776insNPHVC + EGFR H773delinsYNPY + EGFR H773delinsYPNPY + EGFR H773_V774insHPH + EGFR H773_V774insTH1
SunvozertinibLung Non-Small Cell CarcinomaCURATED_BROADERPredictiveASupports Sensitivity Response4accepted
EID12634

In a multinational open label phase II dose randomized study of sunvozertinib in platinum pretreated advanced NSCLC with EGFR exon 20 insertion mutations (WU-KONG1B, NCT03974022; efficacy n = 85 for 2… (full text at CIViC)

PMID 40923280 · Yang et al., 2025 · Open in CIViC

civic
EGFR A763_Y764insFQEA + EGFR D770_N771insG + EGFR D770_N771insH + EGFR H773_V774insAH + EGFR H773_V774insH + EGFR H773_V774insNPH + EGFR H773_V774insPH + EGFR N771dup + EGFR V774_C775insHV1
SunvozertinibLung Non-Small Cell CarcinomaCURATED_BROADERPredictiveASupports Sensitivity Response4accepted
EID12630

In a multinational open label phase II dose randomized study of sunvozertinib in platinum pretreated advanced NSCLC with EGFR exon 20 insertion mutations (WU-KONG1B, NCT03974022; efficacy n = 85 for 2… (full text at CIViC)

PMID 40923280 · Yang et al., 2025 · Open in CIViC

civic
EGFR H773delinsNPY + EGFR H773delinsPNPY + EGFR N771delinsGY + EGFR N771_P772insRH + EGFR N771_P772insVDN + EGFR P772delinsHR + EGFR P772_H773insDNP + EGFR P772_H773insPHP + EGFR P772_H773insQ + EGFR P772_H773insRNP + EGFR P772_H773insYNP1
SunvozertinibLung Non-Small Cell CarcinomaCURATED_BROADERPredictiveASupports Sensitivity Response4accepted
EID12633

In a multinational open label phase II dose randomized study of sunvozertinib in platinum pretreated advanced NSCLC with EGFR exon 20 insertion mutations (WU-KONG1B, NCT03974022; efficacy n = 85 for 2… (full text at CIViC)

PMID 40923280 · Yang et al., 2025 · Open in CIViC

civic
EGFR A767_V769dupASV + EGFR S768_D770dup1
SunvozertinibLung Non-Small Cell CarcinomaCURATED_BROADERPredictiveASupports Sensitivity Response4accepted
EID12623

In a multinational open label phase II dose randomized study of sunvozertinib in platinum pretreated advanced NSCLC with EGFR exon 20 insertion mutations (WU-KONG1B, NCT03974022; efficacy n = 85 for 2… (full text at CIViC)

PMID 40923280 · Yang et al., 2025 · Open in CIViC

civic