Publication
Genomic characterization of tumor mutational burden-high breast carcinomas.
Authors not recorded
NPJ Precis Oncol2025PMID 40775459PMC12331897stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- cancerBreast Carcinomacivic_curation1.00
- variantHighcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 40775459
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| High1 | ||||||||
| (diagnostic) | Breast Carcinoma | Diagnostic | B | Supports Positive | 3 | accepted | EID13105Tumor mutational burden (TMB) derived from MSK-IMPACT targeted next-generation sequencing was evaluated in 7,894 breast cancers, from which 527 TMB-high tumors from 462 patients were identified. Tumor… (full text at CIViC) PMID 40775459 · Vougiouklakis et al., 2025 · Open in CIViC | civic |