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Safety, effectiveness and pharmacokinetics of high-dose propylene glycol-free melphalan (EVOMELA) with a prolonged infusion as myeloablative conditioning in Chinese multiple myeloma patients undergoing autologous stem cell transplantation: A prospective phase iv study.

Fengrong Wang, Zhen Cai, Dehui Zou, Wenming Chen, Yongping Song, Chengcheng Fu, Jiong Hu, Ting Yang, Xinchuan Chen, Jinsong Yan, Kaiyan Liu

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy PractitionersOct 1, 2026PMID 40296724doi:10.1177/10781552251336172 Journal ArticleClinical Trial, Phase IVpubmedProvenance
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PubMed
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Oct 1, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20261001-000001
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BackgroundMelphalan formulated with modified cyclodextrin (β-cyclodextrin sulfobutyl ether sodium [BSES]) is widely used before autologous stem cell transplantation (ASCT) in patients with multiple myeloma (MM) because of its favorable solubility and stability versus conventional melphalan, but the…

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