Publication
Cyclin-Dependent Kinase 4/6 Inhibition as a Novel Therapy for Peritoneal Mucinous Carcinomatosis With GNAS Mutations.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Appendix Neoplasmcivic_curation1.00
- cancerPseudomyxoma Peritoneicivic_curation1.00
- drugPalbociclibcivic_curation1.00
- geneGNAScivic_curation1.00
- variantGNAS Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 39413348
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GNAS Mutation2 | ||||||||
| Palbociclib | Malignant Appendix NeoplasmALIAS | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID13145In ex vivo human tumor slice models of mucinous cancers, GNAS-mutant tumors showed greater sensitivity to palbociclib than GNAS wild-type (WT) tumors, with significantly reduced proliferation followin… (full text at CIViC) PMID 39413348 · Weitz et al., 2025 · Open in CIViC | civic |
| 〃 | Pseudomyxoma Peritonei | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID13146This paper details a prospective single-arm personalized cancer therapy study with n = 16 patients. The disease type was peritoneal mucinous carcinomatosis, predominantly of appendiceal origin. Palboc… (full text at CIViC) PMID 39413348 · Weitz et al., 2025 · Open in CIViC | civic |