Publication
Acquired multiple mutations ALK I1171N, L1196M and G1202R mediate lorlatinib resistance in EML4-ALK-rearranged malignant pleural mesothelioma: a case report.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerPleural Malignant Mesotheliomacivic_curation1.00
- drugAlectinibcivic_curation1.00
- drugLorlatinibcivic_curation1.00
- geneALKcivic_curation1.00
- variantALK Fusioncivic_curation1.00
- variantALK G1202Rcivic_curation1.00
- variantALK I1171Ncivic_curation1.00
- variantALK L1196Mcivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 32600123
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ALK Fusion1 | ||||||||
| Alectinib | Pleural Malignant MesotheliomaALIAS | Predictive | C | Supports Sensitivity Response | 4 | accepted | EID9228A 33 year old M non-smoker with no cancer family history and no known exposure to asbestos showed weakness, chest pain, and plural effusion (PE) accumulation. Mass in right lung was seen under enhance… (full text at CIViC) PMID 32600123 · Hu et al., 2020 · Open in CIViC | civic |
| ALK G1202R + ALK I1171N + ALK L1196M + ALK Fusion1 | ||||||||
| Lorlatinib | Pleural Malignant MesotheliomaALIAS | Predictive | C | Supports Resistance | 3 | accepted | EID11114This case report describes a 33 year-old non-smoker with no known exposure to asbestos who was diagnosed with stage IIIB malignant pleural mesothelioma. Panel next generation sequencing (NGS) of 520 g… (full text at CIViC) PMID 32600123 · Hu et al., 2020 · Open in CIViC | civic |
| ALK I1171N + ALK L1196M + ALK Fusion2 | ||||||||
| Alectinib | Pleural Malignant MesotheliomaALIAS | Predictive | C | Supports Resistance | 4 | accepted | EID11115A 33 year old male with no smoking history or known exposure to asbestos was diagnosed with malignant pleural mesothelioma (MPM). EML4::ALK was found using a panel of 520 genes in NGS, and the patient… (full text at CIViC) PMID 32600123 · Hu et al., 2020 · Open in CIViC | civic |
| Lorlatinib | Pleural Malignant MesotheliomaALIAS | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID11113This case report describes a 33 year-old non-smoker with no known exposure to asbestos who was diagnosed with stage IIIB malignant pleural mesothelioma. Panel next generation sequencing (NGS) of 520 g… (full text at CIViC) PMID 32600123 · Hu et al., 2020 · Open in CIViC | civic |