Publication
Prevalence of PRKDC mutations and association with response to immune checkpoint inhibitors in solid tumors.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 10, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260910-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerLung Non-Small Cell Carcinomacivic_curation1.00
- cancerMelanomacivic_curation1.00
- drugAnti-CTLA-4 Monoclonal Antibodycivic_curation1.00
- drugAnti-PD1 Monoclonal Antibodycivic_curation1.00
- genePRKDCcivic_curation1.00
- variantPRKDC Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 32502294
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PRKDC Mutation2 | ||||||||
| Anti-CTLA-4 Monoclonal Antibody + Anti-PD1 Monoclonal AntibodyCombination | Lung Non-Small Cell CarcinomaCURATED_BROADER | Predictive | B | Supports Sensitivity Response | 2 | accepted | EID13225In a retrospective analysis of the Hellmann cohort of 75 patients with non-small cell lung cancer treated with combined PD-1 and CTLA-4 blockade, 6 patients with nonsynonymous PRKDC mutations had a hi… (full text at CIViC) PMID 32502294 · Chen et al., 2020 · Open in CIViC | civic |
| Anti-CTLA-4 Monoclonal Antibody | Melanoma | Predictive | B | Supports Sensitivity Response | 2 | accepted | EID13226In a retrospective analysis of the Allen cohort of 110 patients with advanced melanoma treated with CTLA-4 blockade, 9 patients with nonsynonymous PRKDC mutations had a higher objective response rate … (full text at CIViC) PMID 32502294 · Chen et al., 2020 · Open in CIViC | civic |