Publication
Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor-Positive Metastatic Breast Cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Breast Neoplasmcivic_curation1.00
- drugFulvestrantcivic_curation1.00
- drugPalbociclibcivic_curation1.00
- geneCCNE1civic_curation1.00
- variantCCNE1 Underexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 30807234
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CCNE1 Underexpression1 | ||||||||
| Fulvestrant + PalbociclibCombination | Malignant Breast Neoplasm | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID7331This retrospective study analyzed the association between the gene expression and the effectiveness of adding palbociclib to fulvestrant. The PALOMA-3 trial randomly assigned 521 endocrine-pretreated … (full text at CIViC) PMID 30807234 · Turner et al., 2019 · Open in CIViC | civic |
| CDK6 Overexpression1 | ||||||||
| Palbociclib | Malignant Breast Neoplasm | Predictive | B | Does Not Support Sensitivity Response | 3 | submitted | EID11200The PALOMA-3 trial compared palbociclib plus fulvestrant vs placebo plus fulvestrant and evaluated molecular correlates of response in 302 patients with metastatic breast cancer. mRNA expression level… (full text at CIViC) PMID 30807234 · Turner et al., 2019 · Open in CIViC | civic |