Publication
Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- drugAfatinibcivic_curation1.00
- geneNRG1civic_curation1.00
- variantNRG1 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 29610121
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NRG1 Fusion2 | ||||||||
| Afatinib | Mucinous Lung AdenocarcinomaUNRESOLVED | Predictive | C | Does Not Support Sensitivity Response | 3 | accepted | EID6096One patient with an NRG1-rearranged invasive mucinous adenocarcinomas (IMAs) of the lung had a response with an anti-ERBB3 monoclonal antibody (GSK2849330). No response was achieved with afatinib in f… (full text at CIViC) PMID 29610121 · Drilon et al., 2018 · Open in CIViC | civic |
| Anti-HER3 Monoclonal Antibody GSK2849330 | Mucinous Lung AdenocarcinomaUNRESOLVED | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID6095One patient with an NRG1-rearranged invasive mucinous adenocarcinomas (IMAs) of the lung had a response with an anti-ERBB3 monoclonal antibody (GSK2849330). No response was achieved with afatinib in f… (full text at CIViC) PMID 29610121 · Drilon et al., 2018 · Open in CIViC | civic |