Publication
RET mutation heterogeneity in primary advanced medullary thyroid cancers and their metastases.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerThyroid Gland Medullary Carcinomacivic_curation1.00
- geneRETcivic_curation1.00
- variantRET M918Tcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 29515777
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RET D898_E901del + RET E632_L633del1 | ||||||||
| (oncogenic) | Thyroid Gland Medullary CarcinomaALIAS | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID12710In a study of 56 Medullary Thyroid Cancer patients (50 somatic and 6 hereditary) two patients had somatic p.E632_L633del. One of them had p.E632_L633del and p.D898_E901del found in lymph node metasta… (full text at CIViC) PMID 29515777 · Romei et al., 2018 · Open in CIViC | civic |
| RET M918T1 | ||||||||
| (predisposing) | Thyroid Gland Medullary CarcinomaALIAS | Predisposing | C | Supports Predisposition | 2 | accepted | EID12711A total of 56 metastatic medullary thyroid cancer cases (50 sporadic, 6 familial) were analyzed for RET mutations. A total of 7 cases were found to have a RET germline mutations however one case had a… (full text at CIViC) PMID 29515777 · Romei et al., 2018 · Open in CIViC | civic |