Publication
ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMucosal Melanomacivic_curation1.00
- drugEntrectinibcivic_curation1.00
- geneALKcivic_curation1.00
- variantALK Alternative Transcript (ATI)civic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 29054983
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ALK Alternative Transcript (ATI)2 | ||||||||
| Alectinib + ALK Inhibitor ASP3026 + Ceritinib + Crizotinib + EntrectinibSubstitutes | Melanoma | Predictive | D | Does Not Support Sensitivity Response | 3 | submitted | EID7484Melanoma cell lines and xenografts expressing the ALK ATI variant did not respond to treatment with ALK inhibitors, while fusion ALK expressing cell lines and xenografts were sensitive. PMID 29054983 · Couts et al., 2018 · Open in CIViC | civic |
| Entrectinib | Mucosal Melanoma | Predictive | C | Does Not Support Sensitivity Response | 4 | accepted | EID7421ALK expression was analyzed in 45 melanoma patient-derived xenografts (PDXs), with 11/45 showing ALK expression. Four PDX tumours had only wild-type ALK expression, four had only ALK alternative trans… (full text at CIViC) PMID 29054983 · Couts et al., 2018 · Open in CIViC | civic |