Publication
Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies.
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Br J Cancer2017PMID 28595259PMC5520517stubpubmedProvenance
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- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
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civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
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- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28595259
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KIT M541L1 | ||||||||
| Imatinib | Colon Signet Ring AdenocarcinomaUNRESOLVED | Predictive | E | Supports Sensitivity Response | 2 | accepted | EID7195In a study of 44 signet ring cell colorectal cancer cases, 25% were found to carry a KIT M541L mutation. The authors speculate that this relatively high frequency of KIT mutations (actionable in other… (full text at CIViC) PMID 28595259 · Alvi et al., 2017 · Open in CIViC | civic |