Publication
A Novel BRCA1-Associated Protein-1 Isoform Affects Response of Mesothelioma Cells to Drugs Impairing BRCA1-Mediated DNA Repair.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Mesotheliomacivic_curation1.00
- drugApitolisibcivic_curation1.00
- drugOlaparibcivic_curation1.00
- geneBAP1civic_curation1.00
- variantBAP1 ALTERNATIVE TRANSCRIPT (ATI)civic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28389374
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BAP1 ALTERNATIVE TRANSCRIPT (ATI)1 | ||||||||
| Apitolisib + OlaparibCombination | Malignant Mesothelioma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID5929A novel alternative splice isoform of BAP1 (BAP1Δ) that misses part of the catalytic domain showed reduced deubiquitinating activity compared with full-length BAP1. 4 MPM cell lines expressing more th… (full text at CIViC) PMID 28389374 · Parrotta et al., 2017 · Open in CIViC | civic |
| BARD1 ISOFORM EXPRESSION1 | ||||||||
| Apitolisib + OlaparibCombination | Pleural Malignant MesotheliomaALIAS | Predictive | D | Supports Sensitivity Response | 3 | rejected | EID5998MPM cells transfected with BAP1Δ, an alternative splice isoform of BAP1 that misses part of the catalytic domain, showed reduced deubiquitinating activity compared with full-length BAP1. MPM cell line… (full text at CIViC) PMID 28389374 · Parrotta et al., 2017 · Open in CIViC | civic |