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Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing.

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Oncotarget2017PMID 28002790PMC5355278stubpubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-CIVIC-20260908-000001
Published

Abstract

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Linked entities

Linked entities (7)

How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.

Validated 7

Curated evidence

Evidence citing this paper (3)

civicProvenance
Source
CIViC — Clinical Interpretation of Variants in Cancer
Dataset
CIViC evidence items
Version
civic-2026-09-08
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Evidence
expert curation
License
CC0 1.0
PMID
28002790
Run
ING-CIVIC-20260908-000001
Open at source CuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.
TherapyCancerTypeLevelDirection · significanceRating (1–5)StatusEvidenceSource
BRAF Fusion3
SelumetinibChildhood Pilocytic AstrocytomaPredictiveDSupports Sensitivity Response2accepted
EID8943

In this preclinical experiment, a pediatric pilocytic astrocytoma cell line (DKFZ-BT66) harboring KIAA1549:BRAF fusion was generated from a two year old patient. Treatment with selumetinib resulted in… (full text at CIViC)

PMID 28002790 · Selt et al., 2017 · Open in CIViC

civic
Sorafenib + VemurafenibSubstitutesChildhood Pilocytic AstrocytomaPredictiveDSupports Resistance2accepted
EID7402

A pilocytic astrocytoma (PA) cell line named DKFZ-BT66 was generated from a 2-year old patient with the disease. Expression of KIAA1549-BRAF fusion in this cell line was identified. Treatment with sor… (full text at CIViC)

PMID 28002790 · Selt et al., 2017 · Open in CIViC

civic
TrametinibChildhood Pilocytic AstrocytomaPredictiveDSupports Sensitivity Response3accepted
EID8944

In this preclinical experiment, a pediatric pilocytic astrocytoma cell line (DKFZ-BT66) harboring KIAA1549:BRAF fusion was generated from a two year old patient. Treatment with trametinib resulted in … (full text at CIViC)

PMID 28002790 · Selt et al., 2017 · Open in CIViC

civic