Publication
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.
Authors not recorded
Cell2016PMID 27667683PMC5088716stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
No abstract stored. Read on PubMed
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerMelanomacivic_curation1.00
- drugIpilimumabcivic_curation1.00
- geneIFNGR1civic_curation1.00
- variantIFNGR1 Losscivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27667683
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| IFNGR1 Loss1 | ||||||||
| Ipilimumab | Melanoma | Predictive | D | Supports Resistance | 2 | accepted | EID12142C57BL/6 mice were inoculated with B16/BL6 tumour cells and treated with anti-CTLA-4 to assess in-vivo effects of IFNGR1 knockdown on tumour growth. All untreated mice with wildtype scramble shRNA-tran… (full text at CIViC) PMID 27667683 · Gao et al., 2016 · Open in CIViC | civic |