Publication
Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma.
Authors not recorded
Clin Cancer Res2017PMID 27535980stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Data not yet available
No abstract stored. Read on PubMed
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerSarcomacivic_curation1.00
- drugFexagratinibcivic_curation1.00
- drugFGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074civic_curation1.00
- drugInfigratinibcivic_curation1.00
- geneFGFR1civic_curation1.00
- variantFGFR1 Expressioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27535980
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FGFR1 Expression1 | ||||||||
| Fexagratinib + FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 + InfigratinibSubstitutes | Sarcoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID2915Targeting of FGFR1 by RNA interference and small-molecule inhibitors (PD173074, AZD4547, BGJ398) revealed that the requirement for FGFR1 signaling in STS cells is dictated by FGFR1 expression levels, … (full text at CIViC) PMID 27535980 · Chudasama et al., 2017 · Open in CIViC | civic |