Publication
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Breast Neoplasmcivic_curation1.00
- drugAlpelisibcivic_curation1.00
- drugSGK1-Inhcivic_curation1.00
- geneSGK1civic_curation1.00
- variantSGK1 Overexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27451907
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| SGK1 Overexpression3 | ||||||||
| Alpelisib | Malignant Breast Neoplasm | Predictive | B | Supports Resistance | 3 | accepted | EID1730A group of 18 breast cancer patients were treated with PI3Kalpha inhibitor alpelisib (NVP-BYL719) plus an aromatase inhbitor (NCT01870505). 3 out of 3 patients expressing high tumor SGK1 mRNA had dise… (full text at CIViC) PMID 27451907 · Castel et al., 2016 · Open in CIViC | civic |
| 〃 | Malignant Breast Neoplasm | Predictive | D | Supports Resistance | 5 | accepted | EID1729SGK1 mRNA expression was elevated in five breast cancer cell lines which were resistant to PI3Kalpha inhibitor alpelisib (NVP-BYL719) in comparison to five sensitive cell lines. Western blots showed c… (full text at CIViC) PMID 27451907 · Castel et al., 2016 · Open in CIViC | civic |
| Alpelisib + SGK1-InhCombination | Malignant Breast Neoplasm | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID1731The alpelisib (PI3Kalpha inhibitor) resistant breast cancer cell line HCC1954 was treated with alpelsisb alone or in combination with the SGK1 kinase inhibitor SGK1-Inh. Addition of SGK1 reduced viabi… (full text at CIViC) PMID 27451907 · Castel et al., 2016 · Open in CIViC | civic |