Publication
Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerMalignant Colorectal Neoplasmcivic_curation1.00
- drugDasatinibcivic_curation1.00
- geneARID1Acivic_curation1.00
- variantARID1A Losscivic_curation1.00
- variantARID1A P1175FS*5civic_curation1.00
- variantARID1A Q456*civic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27364904
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ARID1A Q456*1 | ||||||||
| Dasatinib | Malignant Colorectal NeoplasmCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID4487In an in vitro study, human colorectal cancer cell line HCT116 cell line was made to homozygously express ARID1A Q546* via adeno-associated virus-mediated somatic gene targeting. Compared to the paren… (full text at CIViC) PMID 27364904 · Miller et al., 2016 · Open in CIViC | civic |
| ARID1A Loss1 | ||||||||
| Dasatinib | Ovarian Clear Cell CarcinomaUNRESOLVED | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID2982High-throughput drug screens in OCCC tumor cell model identified synthetic lethal (SL) interaction between the kinase inhibitor dasatinib and ARID1A mutation. Imposing ARID1A deficiency upon a variet… (full text at CIViC) PMID 27364904 · Miller et al., 2016 · Open in CIViC | civic |
| ARID1A P1175FS*51 | ||||||||
| Dasatinib | Ovarian Clear Cell CarcinomaUNRESOLVED | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID4826In an in vitro study, a HCH1 cell line expressing ARID1A P1172fs mutation demonstrated increased sensitivity to dasatinib treatment, compared to ES2, KK and RMG-1 cells expressing wild-type ARID1A. Se… (full text at CIViC) PMID 27364904 · Miller et al., 2016 · Open in CIViC | civic |