Publication
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerColorectal Adenocarcinomacivic_curation1.00
- geneBRAFcivic_curation1.00
- variantBRAF V600Ecivic_curation1.00
- variantHighcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27302369
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| BRAF V600E + High1 | ||||||||
| (prognostic) | Colorectal Adenocarcinoma | Prognostic | B | Supports Poor Outcome | 2 | accepted | EID1940In a study of 468 colorectal adenocarcinoma 61 patients had micro-satellite instability (MSI) and there was a marginally statistically significantly better prognosis for BRAF WT (n=26) patients relati… (full text at CIViC) PMID 27302369 · Schell et al., 2016 · Open in CIViC | civic |
| BRAF APC1 | ||||||||
| (prognostic) | Malignant Colorectal NeoplasmCURATED_BROADER | Prognostic | B | Supports Positive | 3 | rejected | EID1941In a study of 468 colorectal cancer samples, 407 patients had micro-satellite stable tumors and there was a statistically significantly better prognosis for APC WT patients relative to APC-mutated pat… (full text at CIViC) PMID 27302369 · Schell et al., 2016 · Open in CIViC | civic |