Publication
High CDK6 Protects Cells from Fulvestrant-Mediated Apoptosis and is a Predictor of Resistance to Fulvestrant in Estrogen Receptor-Positive Metastatic Breast Cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- drugFulvestrantcivic_curation1.00
- drugPalbociclibcivic_curation1.00
- geneCDK6civic_curation1.00
- variantCDK6 Overexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27252418
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CDK6 Overexpression2 | ||||||||
| Fulvestrant | Estrogen Receptor-positive Breast CancerUNRESOLVED | Predictive | B | Supports Resistance | 4 | accepted | EID1526In two cohorts (n=45 and n=46) of ER+ breast cancer patients who had received fulvestrant, CDK6 overexpression correlated with shorter median time to progression in both cohorts (2.5 vs. 8.2 months an… (full text at CIViC) PMID 27252418 · Alves et al., 2016 · Open in CIViC | civic |
| Fulvestrant + PalbociclibCombination | Estrogen Receptor-positive Breast CancerUNRESOLVED | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID1527Four fulvestrant (estrogen receptor degrader) resistant cell lines were derived from parent fulvestrant sensitive ER+ MCF-7/SO.5 breast cancer cell line. Derivative cell lines showed some sensitivity … (full text at CIViC) PMID 27252418 · Alves et al., 2016 · Open in CIViC | civic |