Publication
Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.
Authors not recorded
Cancer Discov2016PMID 27147599PMC4930723stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- geneNFE2L2civic_curation1.00
- variantNFE2L2 G31Acivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27147599
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NFE2L2 G31A1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | accepted | EID9574The NFE2L2:p.G31A allele was expressed in HA1E-M cells and its tumorigenic potential was tested in a pooled and individual in vivo (mice) assay. The G31A mutation did not lead to tumor formation in th… (full text at CIViC) PMID 27147599 · Kim et al., 2016 · Open in CIViC | civic |