Publication
CIP2A down regulation enhances the sensitivity of pancreatic cancer cells to gemcitabine.
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- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerPancreatic Ductal Adenocarcinomacivic_curation1.00
- drugGemcitabinecivic_curation1.00
- geneCIP2Acivic_curation1.00
- variantCIP2A EXPRESSIONcivic_curation1.00
- variantCIP2A Underexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26894380
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CIP2A EXPRESSION1 | ||||||||
| (prognostic) | Pancreatic Ductal Adenocarcinoma | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID1117Expression of the protein CIP2A was investigated in 72 cases of pancreatic ductal adenocarcinoma and 27 cases of adjacent tissues. Immunohistochemistry revealed a significant difference in expression … (full text at CIViC) PMID 26894380 · Xu et al., 2016 · Open in CIViC | civic |
| CIP2A Underexpression1 | ||||||||
| Gemcitabine | Pancreatic Ductal Adenocarcinoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1118Researchers studied the effect of CIP2A expression in relation to gemcitabine sensitivity via SW1990 cell lines. SW1990 cells with CIP2A expression knocked-down displayed lower IC50 (p=.024), indicat… (full text at CIViC) PMID 26894380 · Xu et al., 2016 · Open in CIViC | civic |